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Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism

Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process. Heterogeneous expression of TM has been observed in cancer, and low or no TM expression in cancer cells is associated with poor prognosis. In th...

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Detalhes bibliográficos
Main Authors: Nocchi, Linda, Tomasetti, Marco, Amati, Monica, Neuzil, Jiri, Santarelli, Lory, Saccucci, Franca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103327/
https://ncbi.nlm.nih.gov/pubmed/21489980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217331
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