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Inappropriate transcription from the 5' end of the murine dihydrofolate reductase gene masks transcriptional regulation.

Using the nuclear run-on assay we found that in proliferating cells the transcription rate in the 5' end of the murine dihydrofolate reductase (dhfr) gene was approximately ten-fold higher than in the 3' end of the gene, suggesting transcriptional attenuation within the dhfr gene. However,...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Schilling, L J, Farnham, P J
Format: Artigo
Language:Inglês
Published: Oxford University Press 1994
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310276/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7520569/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.15.3061
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