Cell Entry and Trafficking of Human Adenovirus Bound to Blood Factor X Is Determined by the Fiber Serotype and Not Hexon:Heparan Sulfate Interaction

Human adenovirus serotype 5 (HAdV5)-based vectors administered intravenously accumulate in the liver as the result of their direct binding to blood coagulation factor X (FX) and subsequent interaction of the FX-HAdV5 complex with heparan sulfate proteoglycan (HSPG) at the surface of liver cells. Int...

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Detalhes bibliográficos
Main Authors: Corjon, Stéphanie, Gonzalez, Gaëlle, Henning, Petra, Grichine, Alexei, Lindholm, Leif, Boulanger, Pierre, Fender, Pascal, Hong, Saw-See
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102659/
https://ncbi.nlm.nih.gov/pubmed/21637339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018205
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