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Genetic Retargeting of Adenovirus: Novel Strategy Employing “Deknobbing” of the Fiber

For efficient and versatile use of adenovirus (Ad) as an in vivo gene therapy vector, modulation of the viral tropism is highly desirable. In this study, a novel method to genetically alter the Ad fiber tropism is described. The knob and the last 15 shaft repeats of the fiber gene were deleted and r...

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Bibliografiske detaljer
Main Authors: Magnusson, Maria K., Hong, Saw See, Boulanger, Pierre, Lindholm, Leif
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114963/
https://ncbi.nlm.nih.gov/pubmed/11462000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7280-7289.2001
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