Genetic Retargeting of Adenovirus: Novel Strategy Employing “Deknobbing” of the Fiber
For efficient and versatile use of adenovirus (Ad) as an in vivo gene therapy vector, modulation of the viral tropism is highly desirable. In this study, a novel method to genetically alter the Ad fiber tropism is described. The knob and the last 15 shaft repeats of the fiber gene were deleted and r...
Gespeichert in:
| Veröffentlicht in: | J Virol |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11462000/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.16.7280-7289.2001 |
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