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Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
Human O(6)–alkylguanine-DNA alkyltransferase (AGT), which directly reverses endogenous alkylation at the O(6)-position of guanine, confers resistance to alkylation chemotherapies and is therefore an active anticancer drug target. Crystal structures of active human AGT and its biologically and therap...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310240/ https://ncbi.nlm.nih.gov/pubmed/10747039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.7.1719 |
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