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Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis

Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor (KDR/FLK1 or VEGFR–2) mediates vascularization and tumor-induced angiogenesis. Since there is evidence that KDR plays an important role in tumor angiogenesis, we sought to identify peptides able to block the VEGF–KDR int...

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Udgivet i:EMBO J
Principais autores: Binétruy-Tournaire, Roselyne, Demangel, Caroline, Malavaud, Bernard, Vassy, Roger, Rouyre, Sylvie, Kraemer, Michel, Plouët, Jean, Derbin, Claude, Perret, Gérard, Mazié, Jean Claude
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310222/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10747021/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.7.1525
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