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Macromolecular crowding fails to fold a globular protein in cells
Proteins perform their function in cells where macromolecular solutes reach concentrations of >300 g/L and occupy >30% of the volume. The volume excluded by these macromolecules will stabilize globular proteins because the native state occupies less space than the denatured state. Theory predi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102155/ https://ncbi.nlm.nih.gov/pubmed/21534566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201206t |
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