FKS1 Mutations Responsible for Selective Resistance of Saccharomyces cerevisiae to the Novel 1,3-β-Glucan Synthase Inhibitor Arborcandin C

Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-β-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn(470) with Lys...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Ohyama, Takao, Miyakoshi, Shunichi, Isono, Fujio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2004
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310202/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14693557/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.1.319-322.2004
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