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Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1
The anaphase promoting complex (APC) is a ubiquitin ligase that promotes the degradation of cell-cycle regulators by the 26S proteasome. Cdc20 and Cdh1 are WD40-containing APC co-activators that bind destruction boxes (DB) and KEN boxes within substrates to recruit them to the APC for ubiquitination...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101997/ https://ncbi.nlm.nih.gov/pubmed/21460798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.90 |
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