Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase

The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10. The inhibition of the sterol pathway results in feedback activation of ERG10 transcription. A cell-based re...

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Главные авторы: Buurman, Ed T., Blodgett, April E., Hull, Kenneth G., Carcanague, Daniel
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC310196/
https://ncbi.nlm.nih.gov/pubmed/14693556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.313-318.2004
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