Deconvolution and Database Search of Complex Tandem Mass Spectra of Intact Proteins: A COMBINATORIAL APPROACH

Top-down proteomics studies intact proteins, enabling new opportunities for analyzing post-translational modifications. Because tandem mass spectra of intact proteins are very complex, spectral deconvolution (grouping peaks into isotopomer envelopes) is a key initial stage for their interpretation....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Xiaowen, Inbar, Yuval, Dorrestein, Pieter C., Wynne, Colin, Edwards, Nathan, Souda, Puneet, Whitelegge, Julian P., Bafna, Vineet, Pevzner, Pavel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101958/
https://ncbi.nlm.nih.gov/pubmed/20855543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.002766
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