Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

BACKGROUND: Although a high level of thymidylate synthase (TS) expression in malignant tumours has been suggested to be related to a reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in non-small cell lung cancer (NSCLC). We have...

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Main Authors: Takezawa, K, Okamoto, I, Okamoto, W, Takeda, M, Sakai, K, Tsukioka, S, Kuwata, K, Yamaguchi, H, Nishio, K, Nakagawa, K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101907/
https://ncbi.nlm.nih.gov/pubmed/21487406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.129
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