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In Vitro Evaluation of Nonnucleoside Reverse Transcriptase Inhibitors UC-781 and TMC120-R147681 as Human Immunodeficiency Virus Microbicides

The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable...

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Published in:Antimicrob Agents Chemother
Main Authors: Van Herrewege, Yven, Michiels, Jo, Van Roey, Jens, Fransen, Katrien, Kestens, Luc, Balzarini, Jan, Lewi, Paul, Vanham, Guido, Janssen, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310190/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14693562/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.1.337-339.2004
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