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Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

Mycobacterium tuberculosis (Mtb) has generated a global health catastrophe that has been compounded by the emergence of drug resistant Mtb strains. We used whole genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolgus macaques with active, latent and reactivated di...

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Bibliografiset tiedot
Päätekijät: Ford, Christopher B., Lin, Philana Ling, Chase, Michael, Shah, Rupal R., Iartchouk, Oleg, Galagan, James, Mohaideen, Nilofar, Ioerger, Thomas R., Sacchettini, James C., Lipsitch, Marc, Flynn, JoAnne L., Fortune, Sarah M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101871/
https://ncbi.nlm.nih.gov/pubmed/21516081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.811
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