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Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
Mycobacterium tuberculosis (Mtb) has generated a global health catastrophe that has been compounded by the emergence of drug resistant Mtb strains. We used whole genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolgus macaques with active, latent and reactivated di...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101871/ https://ncbi.nlm.nih.gov/pubmed/21516081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.811 |
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