Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

Dogs with hemophilia A, hemophilia B, von Willebrand disease (VWD), and factor VII deficiency faithfully recapitulate the severe bleeding phenotype that occurs in humans with these disorders. The first rational approach to diagnosing these bleeding disorders became possible with the development of r...

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Main Authors: Nichols, Timothy C., Dillow, Aaron M., Franck, Helen W.G., Merricks, Elizabeth P., Raymer, Robin A., Bellinger, Dwight A., Arruda, Valder R., High, Katherine A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101868/
https://ncbi.nlm.nih.gov/pubmed/19293459
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