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Spectroscopic Study of the Cobalamin-Dependent Methionine Synthase in the Activation Conformation: Effects of the Y1139 Residue and S-Adenosylmethionine on the B(12) Cofactor

The cobalamin-dependent methionine synthase (MetH) from Escherichia coli is a modular enzyme that catalyzes a methyl-group transfer from methyltetrahydrofolate to homocysteine via a methylcob(III)alamin (MeCbl) intermediate, generating tetrahydrofolate and methionine (Met). Once every ~2000 turnover...

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Detalles Bibliográficos
Autores principales: Liptak, Matthew D., Datta, Supratim, Matthews, Rowena G., Brunold, Thomas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101771/
https://ncbi.nlm.nih.gov/pubmed/19006389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8038129
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