Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression

PURPOSE. To generate and characterize a constitutively active, RPE-specific, cre-expressing transgenic mouse line. This line can be used to create RPE-specific knockouts by crossing with mice harboring loxP-flanked (floxed) genes. METHODS. A transgene construct was assembled with the BEST1 promoter...

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Hauptverfasser: Iacovelli, Jared, Zhao, Chen, Wolkow, Natalie, Veldman, Peter, Gollomp, Kandace, Ojha, Pallavi, Lukinova, Nina, King, Ayala, Feiner, Leonard, Esumi, Noriko, Zack, Donald J., Pierce, Eric A., Vollrath, Douglas, Dunaief, Joshua L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101664/
https://ncbi.nlm.nih.gov/pubmed/21212186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6347
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