Orally Administered Targeted Recombinant Beta-Lactamase Prevents Ampicillin-Induced Selective Pressure on the Gut Microbiota: a Novel Approach to Reducing Antimicrobial Resistance

Antibiotics that are excreted into the intestinal tract promote antibiotic resistance by exerting selective pressure on the gut microbiota. Using a beagle dog model, we show that an orally administered targeted recombinant β-lactamase enzyme eliminates the portion of parenteral ampicillin that is ex...

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Bibliographische Detailangaben
Hauptverfasser: Harmoinen, Jaana, Mentula, Silja, Heikkilä, Matti, van der Rest, Michel, Rajala-Schultz, Päivi J., Donskey, Curtis J., Frias, Rafael, Koski, Pertti, Wickstrand, Nina, Jousimies-Somer, Hannele, Westermarck, Elias, Lindevall, Kai
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310163/
https://ncbi.nlm.nih.gov/pubmed/14693521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.75-79.2004
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