P1A Recombinant β-Lactamase Prevents Emergence of Antimicrobial Resistance in Gut Microflora of Healthy Subjects during Intravenous Administration of Ampicillin

Ipsat P1A is a recombinant β-lactamase which degrades antibiotic residue in the gastrointestinal tract. In an open-label, single-center controlled trial, 36 healthy subjects were randomized to receive (i) ampicillin (1 g intravenously [i.v.] every 6 h [q6h]), (ii) oral P1A recombinant β-lactamase (8...

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Detalhes bibliográficos
Main Authors: Tarkkanen, Ann-Mari, Heinonen, Tuula, Jõgi, Rain, Mentula, Silja, van der Rest, Michel E., Donskey, Curtis J., Kemppainen, Tuomas, Gurbanov, Konstantin, Nord, Carl Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687246/
https://ncbi.nlm.nih.gov/pubmed/19307374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00853-08
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