α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Parkinson’s disease (PD) is characterized pathologically by intraneuronal inclusions called Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus increases α-synuclein expression and causes PD. Thus, overexpression of wild-type α-synuclein is toxic. In this stud...

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Detalhes bibliográficos
Main Authors: Winslow, Ashley R., Chen, Chien-Wen, Corrochano, Silvia, Acevedo-Arozena, Abraham, Gordon, David E., Peden, Andrew A., Lichtenberg, Maike, Menzies, Fiona M., Ravikumar, Brinda, Imarisio, Sara, Brown, Steve, O’Kane, Cahir J., Rubinsztein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101586/
https://ncbi.nlm.nih.gov/pubmed/20855506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201003122
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