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Power of genome-wide association studies in the presence of interacting loci

Though multiple interacting loci are likely involved in the etiology of complex diseases, early genome-wide association studies (GWAS) have depended on the detection of the marginal effects of each locus. Here, we evaluate the power of GWAS in the presence of two linked and potentially associated ca...

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Detalhes bibliográficos
Main Authors: Pickrell, Joseph, Clerget-Darpoux, Françoise, Bourgain, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley-Liss 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101367/
https://ncbi.nlm.nih.gov/pubmed/17508359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20238
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