The fidelity of the human leading and lagging strand DNA replication apparatus with 8-oxodeoxyguanosine triphosphate.

A product of oxidative metabolism, 8-oxodeoxyguanosine triphosphate (8-O-dGTP), readily pairs with adenine during DNA replication, ultimately causing A.T-->C.G transversions. This study utilized 8-O-dGTP as a probe to examine the fidelity of the leading and lagging strand replication apparatus in...

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Bibliographic Details
Main Authors: Minnick, D T, Pavlov, Y I, Kunkel, T A
Format: Artigo
Language:Inglês
Published: 1994
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC310130/
https://ncbi.nlm.nih.gov/pubmed/7838719
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