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Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival

A clustered DNA lesion, also known as a multiply damaged site, is defined as ≥ 2 damages in the DNA within 1–2 helical turns. Only ionizing radiation and certain chemicals introduce DNA damage in the genome in this non-random way. What is now clear is that the lethality of a damaging agent is not ju...

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Detalhes bibliográficos
Main Authors: Sage, Evelyne, Harrison, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101299/
https://ncbi.nlm.nih.gov/pubmed/21185841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2010.12.010
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