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The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function
The stereospecific 5β-reduction of Δ(4)-3-ketosterols is very difficult to achieve chemically and introduces a 90° bend between ring A and B of the planar steroid. In mammals, the reaction is catalyzed by steroid 5β-reductase, a member of the aldo-keto reductase (AKR) family. The human enzyme, AKR1D...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101292/ https://ncbi.nlm.nih.gov/pubmed/21185810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.12.020 |
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