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Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional outcome after spinal cord contusion
Glial cell line-derived trophic factor (GDNF) is a peptide with pleiotropic survival and growth promoting effects on neurons. We found that intraspinal injection of a non-replicating herpes simplex virus (HSV)-based vector coding for GDNF 2 hours after blunt trauma to the thoraco-lumbar spinal cord...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101255/ https://ncbi.nlm.nih.gov/pubmed/20132484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06593.x |
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