Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

Aminoglycoside antibiotics target the ribosomal decoding A-site and are active against a broad spectrum of bacteria. These compounds bind to a highly conserved stem-loop-stem structure in helix 44 of bacterial 16S rRNA. One particular aminoglycoside, paromomycin, also shows potent antiprotozoal acti...

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Bibliografiske detaljer
Main Authors: Hobbie, Sven N., Kaiser, Marcel, Schmidt, Sebastian, Shcherbakov, Dmitri, Janusic, Tanja, Brun, Reto, Böttger, Erik C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101183/
https://ncbi.nlm.nih.gov/pubmed/21629725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001161
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