Cross-Sectional Evidence of a Signaling Pathway from Bone Homeostasis to Glucose Metabolism

CONTEXT: Preclinical studies suggested the existence of a signaling pathway connecting bone and glucose metabolisms. Supposedly leptin modulates osteocalcin bioactivity, which in turn stimulates insulin and adiponectin secretion, and β-cell proliferation. OBJECTIVE: The objective of the investigatio...

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Autors principals: Gravenstein, Kristofer S., Napora, Joshua K., Short, Ryan G., Ramachandran, Ramona, Carlson, Olga D., Metter, E. Jeffrey, Ferrucci, Luigi, Egan, Josephine M., Chia, Chee W.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
Matèries:
Hot Topics in Translational Endocrinology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100745/
https://ncbi.nlm.nih.gov/pubmed/21389141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-2589
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