Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis

The β(2)-integrin CD11b/CD18 mediates the firm adhesion of neutrophils (PMNs) to epithelial monolayers, a key step in PMN transepithelial migration. To complete the transmigration process, adherent PMNs must detach from epithelial monolayer surfaces to move forward. The mechanism that governs the de...

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Main Authors: Zen, Ke, Guo, Ya-Lan, Li, Li-Min, Bian, Zhen, Zhang, Chen-Yu, Liu, Yuan
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Phagocytes, Granulocytes, and Myelopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100697/
https://ncbi.nlm.nih.gov/pubmed/21403131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-287722
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