Substance P (SP)-Neurokinin-1 Receptor (NK-1R) Alters Adipose Tissue Responses to High-Fat Diet and Insulin Action

Peripheral administration of a specific neurokinin-1 receptor (NK-1R) antagonist to mice leads to reduced weight gain and circulating levels of insulin and leptin after high-fat diet (HFD). Here, we assessed the contribution of substance P (SP) and NK-1R in diet-induced obesity using NK-1R deficient...

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Detalhes bibliográficos
Main Authors: Karagiannides, Iordanes, Stavrakis, Dimitris, Bakirtzi, Kyriaki, Kokkotou, Efi, Pirtskhalava, Tamara, Nayeb-Hashemi, Hamed, Bowe, Collin, Bugni, James M., Nuño, Miriam, Lu, Bao, Gerard, Norma P., Leeman, Susan E., Kirkland, James L., Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100617/
https://ncbi.nlm.nih.gov/pubmed/21467195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1345
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