Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals

Normal cells require continuous exposure to growth factors, in order to cross a restriction point and commit to cell cycle progression. This can be replaced by two short, appropriately spaced pulses of growth factors, where the first pulse primes a process, which is completed by the second pulse, an...

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Autori principali: Zwang, Yaara, Sas-Chen, Aldema, Drier, Yotam, Shay, Tal, Avraham, Roi, Lauriola, Mattia, Shema, Efrat, Lidor-Nili, Efrat, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Lu, Yiling, Mills, Gordon B, Rechavi, Gideon, Oren, Moshe, Domany, Eytan, Yarden, Yosef
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100487/
https://ncbi.nlm.nih.gov/pubmed/21596316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.04.017
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