The Role of miR-103 and miR-107 in Regulation of CDK5R1 Expression and in Cellular Migration

CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function, suggesting that a tightly controlled regulation...

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Main Authors: Moncini, Silvia, Salvi, Alessandro, Zuccotti, Paola, Viero, Gabriella, Quattrone, Alessandro, Barlati, Sergio, De Petro, Giuseppina, Venturin, Marco, Riva, Paola
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100319/
https://ncbi.nlm.nih.gov/pubmed/21625387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020038
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