The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.

CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function, suggesting that a tightly controlled regulation...

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Main Authors: Silvia Moncini, Alessandro Salvi, Paola Zuccotti, Gabriella Viero, Alessandro Quattrone, Sergio Barlati, Giuseppina De Petro, Marco Venturin, Paola Riva
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3100319?pdf=render
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