Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

BACKGROUND: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require...

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Hauptverfasser: Chen, Tian Sheng, Arslan, Fatih, Yin, Yijun, Tan, Soon Sim, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Padmanabhan, Jayanthi, Lee, Chuen Neng, de Kleijn, Dominique PV, Lim, Sai Kiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100248/
https://ncbi.nlm.nih.gov/pubmed/21513579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-47
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