Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans

Type 2 diabetes is a global problem, and current ineffective therapeutic strategies pave the way for novel treatments like small molecular activators targeting glucokinase (GCK). GCK activity is fundamental to beta cell and hepatocyte glucose metabolism, and heterozygous activating and inactivating...

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Главные авторы: Beer, Nicola L., van de Bunt, Martijn, Colclough, Kevin, Lukacs, Christine, Arundel, Paul, Chik, Constance L., Grimsby, Joseph, Ellard, Sian, Gloyn, Anna L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099725/
https://ncbi.nlm.nih.gov/pubmed/21454522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.223362
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