A 4-Selenocysteine, 2-Selenocysteine Insertion Sequence (SECIS) Element Methionine Sulfoxide Reductase from Metridium senile Reveals a Non-catalytic Function of Selenocysteines

Selenocysteine (Sec) residues occur in thiol oxidoreductase families, and functionally characterized selenoenzymes typically have a single Sec residue used directly for redox catalysis. However, how new Sec residues evolve and whether non-catalytic Sec residues exist in proteins is not known. Here,...

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Detalhes bibliográficos
Main Authors: Lee, Byung Cheon, Lobanov, Alexey V., Marino, Stefano M., Kaya, Alaattin, Seravalli, Javier, Hatfield, Dolph L., Gladyshev, Vadim N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099691/
https://ncbi.nlm.nih.gov/pubmed/21393246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229807
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