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Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases

Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many selenoproteins have fully functional orthologs, wherein cysteine (Cys) occupies the position of Sec. The reason why some enzymes evolve into selenoprotein...

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מידע ביבליוגרפי
Main Authors: Kim, Hwa-Young, Gladyshev, Vadim N
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1278935/
https://ncbi.nlm.nih.gov/pubmed/16262444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030375
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