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Evolution of Two Modes of Intrinsic RNA Polymerase Transcript Cleavage

During gene transcription, the RNA polymerase (Pol) active center can catalyze RNA cleavage. This intrinsic cleavage activity is strong for Pol I and Pol III but very weak for Pol II. The reason for this difference is unclear because the active centers of the polymerases are virtually identical. Her...

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Detalhes bibliográficos
Main Authors: Ruan, Wenjie, Lehmann, Elisabeth, Thomm, Michael, Kostrewa, Dirk, Cramer, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099687/
https://ncbi.nlm.nih.gov/pubmed/21454497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222273
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