Evolution of Two Modes of Intrinsic RNA Polymerase Transcript Cleavage

During gene transcription, the RNA polymerase (Pol) active center can catalyze RNA cleavage. This intrinsic cleavage activity is strong for Pol I and Pol III but very weak for Pol II. The reason for this difference is unclear because the active centers of the polymerases are virtually identical. Her...

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Bibliografske podrobnosti
Main Authors: Ruan, Wenjie, Lehmann, Elisabeth, Thomm, Michael, Kostrewa, Dirk, Cramer, Patrick
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099687/
https://ncbi.nlm.nih.gov/pubmed/21454497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222273
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