Intradermal Vaccinations With RNA Coding for TAA Generate CD8(+) and CD4(+) Immune Responses and Induce Clinical Benefit in Vaccinated Patients

The aim of this phase I/II nonrandomized trial was to assess feasibility, safety as well as immunological and clinical responses of a mRNA-based vaccination in patients with stage IV renal cell cancer using granulocyte-macrophage colony stimulating factor (GM-CSF) as adjuvant. Intradermal injections...

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Bibliografische gegevens
Hoofdauteurs: Rittig, Susanne M, Haentschel, Maik, Weimer, Katrin J, Heine, Annkristin, Muller, Martin R, Brugger, Wolfram, Horger, Marius S, Maksimovic, Olga, Stenzl, Arnulf, Hoerr, Ingmar, Rammensee, Hans-Georg, Holderried, Tobias AW, Kanz, Lothar, Pascolo, Steve, Brossart, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098631/
https://ncbi.nlm.nih.gov/pubmed/21189474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.289
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