Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders

Mitochondrial defects in gene expression have been implicated in the pathophysiology of bipolar disorder and schizophrenia. We have now contrasted control brains with low pH versus high pH and showed that 28% of genes in mitochondrial-related pathways meet criteria for differential expression. A maj...

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Bibliographic Details
Main Authors: Vawter, MP, Tomita, H, Meng, F, Bolstad, B, Li, J, Evans, S, Choudary, P, Atz, M, Shao, L, Neal, C, Walsh, DM, Burmeister, M, Speed, T, Myers, R, Jones, EG, Watson, SJ, Akil, H, Bunney, WE
Format: Artigo
Language:Inglês
Published: 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098558/
https://ncbi.nlm.nih.gov/pubmed/16636682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mp.4001830
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