Effect of Agonal and Postmortem Factors on Gene Expression Profile: Quality Control in Microarray Analyses of Postmortem Human Brain

There are major concerns that specific agonal conditions, including coma and hypoxia, might affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays. In con...

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Detalhes bibliográficos
Main Authors: Tomita, Hiroaki, Vawter, Marquis P., Walsh, David M., Evans, Simon J., Choudary, Prabhakara V., Li, Jun, Overman, Kevin M., Atz, Mary E., Myers, Richard M., Jones, Edward G., Watson, Stanley J., Akil, Huda, Bunney, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098566/
https://ncbi.nlm.nih.gov/pubmed/14960286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2003.10.013
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