Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

Apoptosis provoked by glucose shortage in dividing T cells is mediated via the BH3-only protein Noxa and inhibition of its binding partner Mcl-1. It is unknown how signals from cellular metabolism can affect the balance between Mcl-1 and Noxa and to what extent other Bcl-2 members are involved in th...

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Hlavní autoři: Wensveen, Felix M., Alves, Nuno L., Derks, Ingrid A. M., Reedquist, Kris A., Eldering, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2011
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098366/
https://ncbi.nlm.nih.gov/pubmed/21516346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-011-0599-8
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