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Kinetic Mechanism for the Excision of Hypoxanthine by Escherichia coli AlkA and Evidence for Binding to DNA Ends

The Escherichia coli 3-methyladenine DNA glycosylase II protein (AlkA) recognizes a broad range of oxidized and alkylated base lesions and catalyzes the hydrolysis of the N-glycosidic bond to initiate the base excision repair pathway. Although the enzyme was one of the first DNA repair glycosylases...

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Detalles Bibliográficos
Main Authors: Zhao, Boyang, O’Brien, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098123/
https://ncbi.nlm.nih.gov/pubmed/21491902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200232c
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