DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

The Escherichia coli AlkA protein is a base excision repair glycosylase that removes a variety of alkylated bases from DNA. The 2.5 Å crystal structure of AlkA complexed to DNA shows a large distortion in the bound DNA. The enzyme flips a 1–azaribose abasic nucleotide out of DNA and induces a 66° be...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Hollis, Thomas, Ichikawa, Yoshitaka, Ellenberger, Tom
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2000
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305614/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10675345/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.4.758
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