Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.

6-Azathymidine, 6-aza-2'-deoxycytidine, 6-methyl-2'-deoxyuridine, and 5,6-dimethyl-2'-deoxyuridine nucleosides have been converted to phosphoramidite synthons and incorporated into oligodeoxynucleotides (ODNs). ODNs containing from 1 to 5 of these modified pyrimidines were compared wi...

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Detalles Bibliográficos
Main Authors: Sanghvi, Y S, Hoke, G D, Freier, S M, Zounes, M C, Gonzalez, C, Cummins, L, Sasmor, H, Cook, P D
Formato: Artigo
Idioma:Inglês
Publicado: 1993
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC309755/
https://ncbi.nlm.nih.gov/pubmed/8393563
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