Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.

6-Azathymidine, 6-aza-2'-deoxycytidine, 6-methyl-2'-deoxyuridine, and 5,6-dimethyl-2'-deoxyuridine nucleosides have been converted to phosphoramidite synthons and incorporated into oligodeoxynucleotides (ODNs). ODNs containing from 1 to 5 of these modified pyrimidines were compared with known 2'-deo...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Sanghvi, Y S, Hoke, G D, Freier, S M, Zounes, M C, Gonzalez, C, Cummins, L, Sasmor, H, Cook, P D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1993
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.14.3197
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