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Free Energy Simulations of a GTPase: GTP and GDP Binding to Archaeal Initiation Factor 2

[Image: see text] Archaeal initiation factor 2 (aIF2) is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, “ON” conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, “OFF” conformation, it dissociates from tRNA. To understand the s...

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Hlavní autoři: Satpati, Priyadarshi, Clavaguéra, Carine, Ohanessian, Gilles, Simonson, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097523/
https://ncbi.nlm.nih.gov/pubmed/21534562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp201934p
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