Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process

Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants new strategies still needed to improve overall patient survival. In this study, we investigated vivo the effects of RAD001 (Everolimus®), a new orally availabl...

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Autori principali: Moriceau, Gatien, Ory, Benjamin, Mitrofan, Laura, Riganti, Chiara, Blanchard, Frédéric, Brion, Régis, Charrier, Céline, Battaglia, Séverine, Pilet, Paul, Denis, Marc, Shultz, Leonard D., Mönkkönen, Jukka, Rédini, Françoise, Heymann, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097388/
https://ncbi.nlm.nih.gov/pubmed/20971812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0578
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