Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains: G(q) Binds Caveolin to Concentrate in Caveolae, whereas G(i) and G(s) Target Lipid Rafts by Default

Select lipid-anchored proteins such as glycosylphosphatidylinositol (GPI)-anchored proteins and nonreceptor tyrosine kinases may preferentially partition into sphingomyelin-rich and cholesterol-rich plasmalemmal microdomains, thereby acquiring resistance to detergent extraction. Two such domains, ca...

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Autors principals: Oh, Phil, Schnitzer, Jan E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2001
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC30973/
https://ncbi.nlm.nih.gov/pubmed/11251080
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