Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

BACKGROUND: The C-terminal domain (CTD) of HIV-1 capsid (CA), like full-length CA, forms dimers in solution and CTD dimerization is a major driving force in Gag assembly and maturation. Mutations of the residues at the CTD dimer interface impair virus assembly and render the virus non-infectious. Th...

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Main Authors: Zhang, Hongtao, Curreli, Francesca, Zhang, Xihui, Bhattacharya, Shibani, Waheed, Abdul A, Cooper, Alan, Cowburn, David, Freed, Eric O, Debnath, Asim K
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097154/
https://ncbi.nlm.nih.gov/pubmed/21539734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-28
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